Ayurveda understands clearly the process of metabolic toxicity. When the body undergoes improper metabolism of food in the gastro-intestinal system, a toxic substance called aama may develop. Initially, this toxic aama will be isolated in the gut and may be excreted through the feces, but if aama continues to accumulate through abnormal diet and digestion, it will spread through the rasa (plasma) and travel to a weakened dhatus (body tissues). Aama creates the substrate for disease. For this reason, Ayurveda always targets the elimination of aama from the body during any panchakarma (detoxification) or rasayana (rejuvenation) protocol.